Spontaneous Explosions

I just realized there is a way for Marvel to keep Agents of Shield canon.

If you watch the show, and follow the MCU closely, you'll see the show creates massive plot holes. But they can fix it, with the upcoming Loki Disney Plus show. 

We know that show will have Loki traveling through time and universes, so perhaps he goes to the universe where AOS happens,(before the show starts) and cause mischief.

Just a thought, I guess.